Estimation of Glomerular Filtration Rate Using Serum Cystatin C as an Early Predictor of Renal Insufficiency in Overweight/ Obese Children and Adolescents with Non-alcoholic Fatty Liver Disease

Background: NAFLD is a clinical spectrum ranging from steatosis (fatty infiltration) to with inflammation, necrosis, fibrosis and cirrhosis resembling alcoholic hepatitis in the absence of abuse. The aim this work was determine early renal functional alterations overweight / obese children adolescents NAFLD, as assessed by estimated glomerular filtration rate using cystatin C, evaluate its relation degree various clinic-laboratory parameters NAFLD.
 Methods: This case control research included 60 adolescent. Cases were classified into two equal groups: group 1: or 2: without NAFLD. Twenty healthy age-and-sex matched BMI less than 85th percentile for age sex chosen controls.
 Results: There significantly positive correlation among serum C weight, BMI, Waist/Hip ratio, ALT, AST, cholesterol, Hip circumference, Fasting plasma insulin Insulin resistance. negative eGFR. significant correlations between eGFR weight z score, hip waist/hip fasting insulin, resistance C.
 Conclusions: Serum Cystatin correlated hepatic steatosis. Values lower patients compared those controls. reduction statistically Levels W/H cholesterol